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SYRE in the 13F filings

Spyre Therapeutics Inc · CUSIP 00773J202

Sector · Pharmaceuticals and biotechnologyTheme · Healthcare: biopharma and medtech· L3VLUP-definedTheme · Pharmaceutical preparations
Quarter
Q2 2026Q1 2026Q4 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Quarter end
30 Jun 2026
the date the book describes
Filed
27 Oct 2026
latest of these filings; the earliest 12 Aug 2026
Managers listing it
28
at least, of 95 tracked, among listed positions
Comparable managers
91
filed both Q1 2026 and Q2 2026; 4 listed it in both
Shares listed
25,618,832
combined, among listed positions
Reported value
$2.3bn
combined, at the quarter end

AllianceBernstein LP. Values in this filing are at the previous quarter end's prices; its share count is the quarter end's.

Among the 91 comparable managers: 23 buyers (opened or added shares) and 6 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was +7,017,948.

Managers listing SYRE in Q2 2026

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q1 2026, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

28 of 28 holders

ActionFiling
Fidelity (FMR LLC)13,026,187$1.2bn0.05%Added+1,245,16313 Aug 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc2,960,855$263munder 0.1%Added+1,362,12514 Aug 2026 (the filing on sec.gov)
Capital World Investors2,315,553$206munder 0.1%Added+1,648,98912 Aug 2026 (the filing on sec.gov)
Janus Henderson Group Ltd2,206,936$196m0.08%Added+550,77214 Aug 2026 (the filing on sec.gov)
Wellington Management Group LLP1,581,505$140munder 0.1%Trimmed-243,30614 Aug 2026 (the filing on sec.gov)
Holocene Advisors LP1,015,170$90m0.20%Newnew14 Aug 2026 (the filing on sec.gov)
Marshall Wace LLP991,693$88m0.07%Added+852,43413 Aug 2026 (the filing on sec.gov)
Woodline Partners LP306,049$27m0.08%Added+40,15714 Aug 2026 (the filing on sec.gov)
Millennium Management LLC196,712$17munder 0.1%Added+50,07314 Aug 2026 (the filing on sec.gov)
Neuberger Berman Group LLC180,884$16munder 0.1%Newnew27 Oct 2026 (the filing on sec.gov)
Balyasny Asset Management LLC147,042$13munder 0.1%Added+91,56514 Aug 2026 (the filing on sec.gov)
Squarepoint Ops LLC139,605$12munder 0.1%Newnew14 Aug 2026 (the filing on sec.gov)
Invesco Ltd120,541$11munder 0.1%Trimmed-11,84914 Aug 2026 (the filing on sec.gov)
Citadel Advisors LLC103,100$9.2munder 0.1%Trimmed-5,0352 Sep 2026 (the filing on sec.gov)
Hudson Bay Capital Management LP58,387$5.2munder 0.1%Newnew14 Aug 2026 (the filing on sec.gov)
AllianceBernstein LP92,540$4.7munder 0.1%Added+21,64014 Aug 2026 (the filing on sec.gov)
Susquehanna International Group LLP39,311$3.5munder 0.1%Added+10,34914 Aug 2026 (the filing on sec.gov)
D. E. Shaw & Co.26,452$2.3munder 0.1%Newnew14 Aug 2026 (the filing on sec.gov)
AQR Capital Management LLC22,937$2.0munder 0.1%Added+2,06314 Aug 2026 (the filing on sec.gov)
Freestone Grove Partners LP22,777$2.0munder 0.1%Newnew14 Aug 2026 (the filing on sec.gov)
Schonfeld Strategic Advisors LLC19,089$1.7munder 0.1%Newnew14 Aug 2026 (the filing on sec.gov)
Two Sigma Investments LP12,771$1.1munder 0.1%Newnew14 Aug 2026 (the filing on sec.gov)
Quantbot Technologies LP8,884$789kunder 0.1%Added+8,79612 Aug 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP8,288$736kunder 0.1%Newnew14 Aug 2026 (the filing on sec.gov)
Man Group PLC7,714$685kunder 0.1%Trimmed-1,83214 Aug 2026 (the filing on sec.gov)
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Largest increases and reductions, by shares

Q1 2026 to Q2 2026, among managers that listed it in both quarters or opened it.

Increases

Reductions

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (11)

Exited (1)

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.
3 in Q1 2024 to 9 in Q2 2026

Tracked managers listing it, at least.

035810Q1 2024Q2 2024Q3 2024Q4 2024Q1 2025Q4 2025Q1 2026Q2 2026
the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.
SYRE by quarter
QuarterHoldersReported valueBuyersSellers
Q1 20243$23m30
Q2 20243$25m30
Q3 20243$45m21
Q4 20244$57m40
Q1 20253$15m12
Q4 20252$69m138
Q1 20265$729m127
Q2 20269$2.2bn236

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

SYRE and LLY →SYRE and JNJ →SYRE and VRTX →Choose a stock to compare with SYRE →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own SYRE, latest filings →Back to the 13F Explorer →