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Which funds own SYRE

Spyre Therapeutics Inc in the Q2 2026 filings. At least 1 of the 91 current managers on file reported a position, worth $90m between them. It is among the largest positions of fewer than a fifth of the current managers on file. Buying and selling roughly cancelled this quarter, which is what a name looks like when the argument is still live.

Managers holding: 1; at least, of 91 current
Combined value: $90m; as reported
Opened: 1; new this quarter
Added to: 0; already held
Trimmed or sold out: 0; 0 sold out entirely

Only each manager’s largest 200 positions are listed here, so a smaller holder may be missing.

Managers reporting a position

Largest first. Weight is the share of that manager’s whole reported book, which is the number worth quoting: $400m is a rounding error in one book and a defining bet in another.

Manager	Value	Weight	Shares	Change on the quarter	Action
Holocene Advisors LP Long/short equity · $44.4bn book	$90m	0.2%	1,015,170	opened1,015,170	New

Ownership through time

At least 9 of the 95 managers whose filings are on file listed SYRE in Q2 2026, against 3 in Q1 2024. 4 managers more than in Q1 2026: 2 started positions; 3 listed it again; 1 no longer listed it among the positions read, which can mean a holding below the listed range, a filing that reported no holdings, or a filing not yet made.

Each manager’s largest 500 positions a quarter are read, so a small holding in a very large book can be missing, and a manager is counted as leaving only where its own filing shows it.

Managers on file listing it

Their combined reported value

Between the quarter ends of Q1 2026 and Q2 2026. Each change in shares is valued at the Q2 2026 price, so the price’s own move is left out; a 13F shows the two quarter ends, not when in between anything was bought or sold.

Started in Q2 2026

Holocene Advisors LP$90m
Freestone Grove Partners LP$2.0m

Largest increases, by shares

Capital World Investors666,564 to 2,315,553 shares+$146m
Fidelity (FMR LLC)11,781,024 to 13,026,187 shares+$111m
Holocene Advisors LPnew: 1,015,170 shares+$90m
Janus Henderson Group Ltd1,656,164 to 2,206,936 shares+$49m
Woodline Partners LP265,892 to 306,049 shares+$3.6m

Largest decreases, by shares

No manager on file sold part of it.

Left it

No manager on file is shown leaving it.

Manager	First listed	Largest	Q2 2026
Fidelity (FMR LLC)	Q1 2026	$1.2bn	$1.2bn
T. Rowe Price Associates Inc	Q2 2026	$263m	$263m
Capital World Investors	Q4 2024	$206m	$206m
Janus Henderson Group Ltd	Q3 2024	$196m	$196m
Wellington Management Group LLP	Q2 2026	$140m	$140m
Holocene Advisors LP	Q2 2026	$90m	$90m
Marshall Wace LLP	Q2 2026	$88m	$88m
Woodline Partners LP	Q1 2024	$27m	$27m
Freestone Grove Partners LP	Q2 2026	$2.0m	$2.0m
Farallon Capital Management LLC	Q1 2024	$18m	last listed Q2 2024
Soros Fund Management LLC	Q1 2024	$5.8m	last listed Q1 2025
ExodusPoint Capital Management LP	Q1 2026	$4.4m	last listed Q1 2026

What SYRE is worth

Knowing who owns it is half the question. The other half is what it is worth against the companies it trades beside, which is the one an interviewer will follow up with.

Build the comp set around SYRE →

How much of the picture this is

A Form 13F reports US-listed long equity and nothing else: no shorts, no bonds, no cash and no non-US listings. It arrives forty-five days after the quarter ends, so a manager who sold in July still shows the position in a filing published in August. This page reads the managers on file here rather than every filer in the market, and each manager’s largest positions rather than the whole table, so a small position in a very large book may not appear. Say “their last filing showed” rather than “they own”, and the distinction will do you credit.

What to do with a name the funds are buying

Knowing who owns something is the start of a pitch, not the pitch. The next questions are what it is worth and why they were buying.

Comps ExplorerValue it against the peers it trades beside Every managerRead any of these books in full Deal tapeWhat buyers paid for whole companies, not slices Hedge fund interviewsHow the room runs, and the stock pitch it wants

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The holdings, every quarter, and the week between

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