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PTGX in the 13F filings

Protagonist Therapeutics Inc · CUSIP 74366E102

Sector · Pharmaceuticals and biotechnologyTheme · Healthcare: biopharma and medtech· L3VLUP-definedTheme · Pharmaceutical preparations
Quarter
Q2 2026Q1 2026Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023
Quarter end
31 Dec 2025
the date the book describes
Filed
27 Oct 2026
latest of these filings; the earliest 10 Feb 2026
Managers listing it
24
at least, of 95 tracked, among listed positions
Comparable managers
92
filed both Q3 2025 and Q4 2025; 7 listed it in both
Shares listed
19,775,566
combined, among listed positions
Reported value
$1.7bn
combined, at the quarter end

Among the 92 comparable managers: 14 buyers (opened or added shares) and 14 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was +4,166,001.

Managers listing PTGX in Q4 2025

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q3 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

24 of 24 holders

ActionFiling
Farallon Capital Management LLC6,144,006$537m2.32%Trimmed-52,00017 Feb 2026 (the filing on sec.gov)
Wellington Management Group LLP3,171,423$277munder 0.1%Added+1,262,97717 Feb 2026 (the filing on sec.gov)
Janus Henderson Group Ltd2,649,981$231m0.10%Added+1,549,16017 Feb 2026 (the filing on sec.gov)
Invesco Ltd1,567,840$137munder 0.1%Added+564,13419 Feb 2026 (the filing on sec.gov)
Woodline Partners LP1,408,772$123m0.48%Trimmed-29,47517 Feb 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc1,400,738$122munder 0.1%Added+180,30217 Feb 2026 (the filing on sec.gov)
Citadel Advisors LLC1,126,687$98munder 0.1%Added+888,80617 Feb 2026 (the filing on sec.gov)
Marshall Wace LLP1,024,925$90m0.08%Trimmed-60,63913 Feb 2026 (the filing on sec.gov)
Fidelity (FMR LLC)539,878$47munder 0.1%Added+19,21417 Feb 2026 (the filing on sec.gov)
Holocene Advisors LP210,019$18munder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
Hudson Bay Capital Management LP109,615$9.6munder 0.1%Newnew13 Feb 2026 (the filing on sec.gov)
Soros Fund Management LLC100,000$8.7m0.10%Newnew13 Feb 2026 (the filing on sec.gov)
Neuberger Berman Group LLC98,473$8.6munder 0.1%Trimmed-24,90427 Oct 2026 (the filing on sec.gov)
AllianceBernstein LP73,222$6.4munder 0.1%Trimmed-187,63217 Feb 2026 (the filing on sec.gov)
Jane Street Group LLC34,307$3.0munder 0.1%Trimmed-10,03212 Feb 2026 (the filing on sec.gov)
Verition Fund Management LLC26,792$2.3munder 0.1%Newnew13 Feb 2026 (the filing on sec.gov)
Polen Capital Management LLC20,349$1.8munder 0.1%Added+2412 Feb 2026 (the filing on sec.gov)
Millennium Management LLC17,391$1.5munder 0.1%Trimmed-110,16917 Feb 2026 (the filing on sec.gov)
Susquehanna International Group LLP11,762$1.0munder 0.1%Trimmed-51,42617 Feb 2026 (the filing on sec.gov)
Winton Group Ltd11,471$1.0munder 0.1%Trimmed-7,09011 Feb 2026 (the filing on sec.gov)
Renaissance Technologies LLC8,167$713kunder 0.1%Newnew12 Feb 2026 (the filing on sec.gov)
Tudor Investment Corp7,718$674kunder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
AQR Capital Management LLC6,954$607kunder 0.1%Trimmed-1,61617 Feb 2026 (the filing on sec.gov)
Arrowstreet Capital LP5,076$443kunder 0.1%Newnew13 Feb 2026 (the filing on sec.gov)

Largest increases and reductions, by shares

Q3 2025 to Q4 2025, among managers that listed it in both quarters or opened it.

Increases

Reductions

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (7)

Exited (4)

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.
3 in Q3 2024 to 7 in Q2 2026

Tracked managers listing it, at least.

0358102017201820192020202120222023202420252026
the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.
PTGX by quarter
QuarterHoldersReported valueBuyersSellers
Q1 20171$231kn.a.n.a.
Q2 20171$197kn.a.n.a.
Q3 20171$458kn.a.n.a.
Q4 20172$19mn.a.n.a.
Q1 20181$8.7mn.a.n.a.
Q2 20182$6.5mn.a.n.a.
Q3 20181$23mn.a.n.a.
Q4 20182$15mn.a.n.a.
Q1 20192$23mn.a.n.a.
Q2 20193$20mn.a.n.a.
Q3 20192$18mn.a.n.a.
Q4 20191$11mn.a.n.a.
Q1 20201$11mn.a.n.a.
Q2 20202$48mn.a.n.a.
Q3 20201$54mn.a.n.a.
Q4 20202$60mn.a.n.a.
Q1 20212$87mn.a.n.a.
Q2 20212$156mn.a.n.a.
Q3 20214$130mn.a.n.a.
Q4 20214$169mn.a.n.a.
Q1 20223$110mn.a.n.a.
Q2 20225$67mn.a.n.a.
Q3 20223$53mn.a.n.a.
Q4 20225$52mn.a.n.a.
Q1 20234$116mn.a.n.a.
Q2 20235$171mn.a.n.a.
Q3 20232$109mn.a.n.a.
Q4 20232$191m20
Q1 20245$248m41
Q2 20243$262m22
Q3 20243$286m21
Q4 20244$253m30
Q1 20254$354m31
Q2 20255$425m41
Q3 20258$790m80
Q4 202510$1.3bn1414
Q1 20269$1.8bn1610
Q2 20267$1.9bn1410

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

PTGX and LLY →PTGX and JNJ →PTGX and VRTX →Choose a stock to compare with PTGX →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own PTGX, latest filings →Back to the 13F Explorer →