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Which funds own PTGX

Protagonist Therapeutics Inc in the Q2 2026 filings. At least 4 of the 91 current managers on file reported a position, worth $1.2bn between them. It is among the largest positions of fewer than a fifth of the current managers on file. Buying and selling roughly cancelled this quarter, which is what a name looks like when the argument is still live.

Managers holding: 4; at least, of 91 current
Combined value: $1.2bn; as reported
Opened: 0; new this quarter
Added to: 0; already held
Trimmed or sold out: 2; 0 sold out entirely

Only each manager’s largest 200 positions are listed here, so a smaller holder may be missing.

Managers reporting a position

Largest first. Weight is the share of that manager’s whole reported book, which is the number worth quoting: $400m is a rounding error in one book and a defining bet in another.

Manager	Value	Weight	Shares	Change on the quarter	Action
Farallon Capital Management LLC Long/short equity · $21.7bn book	$778m	3.6%	6,348,906	+$109m0	Held
Janus Henderson Group Ltd Long-only · $245bn book	$261m	0.1%	2,129,780	-$44m-761,747	Trimmed
Woodline Partners LP Long/short equity · $32.4bn book	$173m	0.5%	1,414,173	+$24m0	Held
Polen Capital Management LLC Long-only · $11.6bn book	$2.8m	0.0%	22,651	+$200k-1,686	Trimmed

Ownership through time

At least 7 of the 95 managers whose filings are on file listed PTGX in Q2 2026, against 1 in Q1 2017. 2 managers fewer than in Q1 2026: 2 no longer listed it among the positions read, which can mean a holding below the listed range or a filing not yet made.

Each manager’s largest 500 positions a quarter are read, so a small holding in a very large book can be missing, and a manager is counted as leaving only where its own filing shows it.

Managers on file listing it

Their combined reported value

Between the quarter ends of Q1 2026 and Q2 2026. Each change in shares is valued at the Q2 2026 price, so the price’s own move is left out; a 13F shows the two quarter ends, not when in between anything was bought or sold.

Started in Q2 2026

No manager on file started a position.

Largest increases, by shares

T. Rowe Price Associates Inc1,665,497 to 2,149,662 shares+$59m

Largest decreases, by shares

Janus Henderson Group Ltd2,891,527 to 2,129,780 shares-$93m
Wellington Management Group LLP3,599,644 to 3,416,781 shares-$22m
Winton Group Ltd12,673 to 10,884 shares-$219k
Polen Capital Management LLC24,337 to 22,651 shares-$207k

Left it

No manager on file is shown leaving it.

Manager	First listed	Largest	Q2 2026
Farallon Capital Management LLC	Q4 2017	$778m	$778m
Wellington Management Group LLP	Q3 2025	$419m	$419m
T. Rowe Price Associates Inc	Q1 2026	$264m	$264m
Janus Henderson Group Ltd	Q3 2025	$305m	$261m
Woodline Partners LP	Q4 2021	$173m	$173m
Polen Capital Management LLC	Q2 2025	$2.8m	$2.8m
Winton Group Ltd	Q3 2024	$1.3m	$1.3m
Marshall Wace LLP	Q1 2023	$90m	last listed Q1 2026
Point72 Asset Management LP	Q4 2020	$83m	last listed Q2 2024
Holocene Advisors LP	Q2 2023	$29m	last listed Q1 2026
Schonfeld Strategic Advisors LLC	Q2 2019	$14m	last listed Q1 2025
Two Sigma Advisers LP	Q2 2023	$11m	last listed Q2 2023
Voloridge Investment Management LLC	Q3 2021	$11m	last listed Q1 2023
Hudson Bay Capital Management LP	Q4 2025	$9.6m	last listed Q4 2025
Soros Fund Management LLC	Q4 2025	$8.7m	last listed Q4 2025
ExodusPoint Capital Management LP	Q4 2018	$8.3m	last listed Q3 2025
Walleye Capital LLC	Q4 2021	$5.7m	last listed Q4 2022

What PTGX is worth

Knowing who owns it is half the question. The other half is what it is worth against the companies it trades beside, which is the one an interviewer will follow up with.

Build the comp set around PTGX →

How much of the picture this is

A Form 13F reports US-listed long equity and nothing else: no shorts, no bonds, no cash and no non-US listings. It arrives forty-five days after the quarter ends, so a manager who sold in July still shows the position in a filing published in August. This page reads the managers on file here rather than every filer in the market, and each manager’s largest positions rather than the whole table, so a small position in a very large book may not appear. Say “their last filing showed” rather than “they own”, and the distinction will do you credit.

What to do with a name the funds are buying

Knowing who owns something is the start of a pitch, not the pitch. The next questions are what it is worth and why they were buying.

Comps ExplorerValue it against the peers it trades beside Every managerRead any of these books in full Deal tapeWhat buyers paid for whole companies, not slices Hedge fund interviewsHow the room runs, and the stock pitch it wants

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The holdings, every quarter, and the week between

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