ALNY in the 13F filings

Alnylam Pharmaceuticals Inc · CUSIP 02043Q107

Sector · Pharmaceuticals and biotechnology Theme · Healthcare: biopharma and medtech· L3VLUP-defined Theme · Pharmaceutical preparations

Quarter

Q3 2026 · early filers Q2 2026 Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024 Q1 2024 Q4 2023

Quarter end: 31 Dec 2025; the date the book describes
Filed: 27 Oct 2026; latest of these filings; the earliest 22 Jan 2026
Managers listing it: 35; at least, of 95 tracked, among listed positions
Comparable managers: 92; filed both Q3 2025 and Q4 2025; 26 listed it in both
Shares listed: 59,125,355; combined, among listed positions
Reported value: $23.5bn; combined, at the quarter end

Among the 92 comparable managers: 15 buyers (opened or added shares) and 28 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was +348,561.

Managers listing ALNY in Q4 2025

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q3 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

ActionShare of book at least

35 of 35 holders

				Action		Filing
Capital World Investors	16,301,772	$6.5bn	0.88%	Trimmed	-132,481	11 Feb 2026 (the filing on sec.gov)
Fidelity (FMR LLC)	15,902,149	$6.3bn	0.32%	Trimmed	-865,476	17 Feb 2026 (the filing on sec.gov)
Capital Research Global Investors	6,779,708	$2.7bn	0.50%	Trimmed	-443,132	11 Feb 2026 (the filing on sec.gov)
Invesco Ltd	5,133,983	$2.0bn	0.19%	Added	+3,652,141	19 Feb 2026 (the filing on sec.gov)
Baillie Gifford & Co	2,600,979	$1.0bn	0.86%	Trimmed	-188,377	23 Jan 2026 (the filing on sec.gov)
Dodge & Cox	1,964,415	$781m	0.42%	Trimmed	-356,815	13 Feb 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc	1,702,831	$677m	0.07%	Trimmed	-97,463	17 Feb 2026 (the filing on sec.gov)
Wellington Management Group LLP	1,628,931	$648m	0.11%	Trimmed	-197,390	17 Feb 2026 (the filing on sec.gov)
Two Sigma Advisers LP	1,132,560	$450m	0.88%	Added	+240,060	17 Feb 2026 (the filing on sec.gov)
Arrowstreet Capital LP	1,127,162	$448m	0.26%	Trimmed	-228,447	13 Feb 2026 (the filing on sec.gov)
AQR Capital Management LLC	919,959	$366m	0.19%	Added	+175,951	17 Feb 2026 (the filing on sec.gov)
Two Sigma Investments LP	616,120	$245m	0.35%	Added	+20,194	17 Feb 2026 (the filing on sec.gov)
Marshall Wace LLP	549,922	$219m	0.20%	Added	+41,551	13 Feb 2026 (the filing on sec.gov)
MFS Investment Management	495,307	$197m	0.06%	Added	+138,778	22 Jan 2026 (the filing on sec.gov)
D. E. Shaw & Co.	444,493	$177m	0.10%	Added	+245,076	17 Feb 2026 (the filing on sec.gov)
Squarepoint Ops LLC	350,969	$140m	0.15%	Added	+205,404	13 Feb 2026 (the filing on sec.gov)
Jane Street Group LLC	311,288	$124m	under 0.1%	Trimmed	-647,462	12 Feb 2026 (the filing on sec.gov)
Susquehanna International Group LLP	191,820	$76m	under 0.1%	Trimmed	-385,812	17 Feb 2026 (the filing on sec.gov)
Voloridge Investment Management LLC	160,577	$64m	0.22%	Trimmed	-196,229	17 Feb 2026 (the filing on sec.gov)
Man Group PLC	144,210	$57m	0.10%	Added	+72,537	17 Feb 2026 (the filing on sec.gov)
Janus Henderson Group Ltd	136,425	$54m	under 0.1%	Added	+570	17 Feb 2026 (the filing on sec.gov)
Neuberger Berman Group LLC	115,203	$46m	under 0.1%	Trimmed	-15,341	27 Oct 2026 (the filing on sec.gov)
Bridgewater Associates LP	85,617	$34m	0.12%	Added	+51,706	13 Feb 2026 (the filing on sec.gov)
Hudson Bay Capital Management LP	85,000	$34m	0.11%	Added	+75,589	13 Feb 2026 (the filing on sec.gov)
Millennium Management LLC	75,430	$30m	under 0.1%	Trimmed	-474,501	17 Feb 2026 (the filing on sec.gov)

Page 1 of 2

Largest increases and reductions, by shares

Q3 2025 to Q4 2025, among managers that listed it in both quarters or opened it.

Increases

Invesco Ltdexisting position · 5,133,983 shares now+3,652,141
D. E. Shaw & Co.existing position · 444,493 shares now+245,076
Two Sigma Advisers LPexisting position · 1,132,560 shares now+240,060
Squarepoint Ops LLCexisting position · 350,969 shares now+205,404
AQR Capital Management LLCexisting position · 919,959 shares now+175,951

Reductions

Fidelity (FMR LLC)existing position · 15,902,149 shares now-865,476
Jane Street Group LLCexisting position · 311,288 shares now-647,462
Millennium Management LLCexisting position · 75,430 shares now-474,501
Capital Research Global Investorsexisting position · 6,779,708 shares now-443,132
Susquehanna International Group LLPexisting position · 191,820 shares now-385,812

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (0)

No new position among listed positions.

Exited (8)

ExodusPoint Capital Management LPwas $14m
Holocene Advisors LPwas $6.0m
Winton Group Ltdwas $3.1m
Point72 Asset Management LPwas $2.8m
Soros Fund Management LLCwas $2.0m
Moore Capital Management LPwas $1.9m
Freestone Grove Partners LPwas $644k
Polen Capital Management LLCwas $316k

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.

18 in Q3 2024 to 21 in Q2 2026

Tracked managers listing it, at least.

the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.

ALNY by quarter
Quarter	Holders	Reported value	Buyers	Sellers
Q2 2013	4	$407m	n.a.	n.a.
Q3 2013	6	$1.2bn	n.a.	n.a.
Q4 2013	7	$1.5bn	n.a.	n.a.
Q1 2014	8	$1.6bn	n.a.	n.a.
Q2 2014	6	$1.7bn	n.a.	n.a.
Q3 2014	7	$2.1bn	n.a.	n.a.
Q4 2014	6	$2.2bn	n.a.	n.a.
Q1 2015	8	$2.9bn	n.a.	n.a.
Q2 2015	6	$3.3bn	n.a.	n.a.
Q3 2015	5	$2.1bn	n.a.	n.a.
Q4 2015	6	$2.7bn	n.a.	n.a.
Q1 2016	8	$2.0bn	n.a.	n.a.
Q2 2016	7	$2.0bn	n.a.	n.a.
Q3 2016	8	$2.6bn	n.a.	n.a.
Q4 2016	8	$1.6bn	n.a.	n.a.
Q1 2017	9	$2.2bn	n.a.	n.a.
Q2 2017	14	$3.8bn	n.a.	n.a.
Q3 2017	15	$5.7bn	n.a.	n.a.
Q4 2017	14	$6.3bn	n.a.	n.a.
Q1 2018	15	$5.7bn	n.a.	n.a.
Q2 2018	15	$4.4bn	n.a.	n.a.
Q3 2018	14	$3.9bn	n.a.	n.a.
Q4 2018	10	$3.3bn	n.a.	n.a.
Q1 2019	11	$4.6bn	n.a.	n.a.
Q2 2019	16	$3.8bn	n.a.	n.a.
Q3 2019	11	$4.4bn	n.a.	n.a.
Q4 2019	13	$6.2bn	n.a.	n.a.
Q1 2020	12	$5.7bn	n.a.	n.a.
Q2 2020	15	$7.7bn	n.a.	n.a.
Q3 2020	13	$7.6bn	n.a.	n.a.
Q4 2020	13	$6.5bn	n.a.	n.a.
Q1 2021	14	$7.2bn	n.a.	n.a.
Q2 2021	13	$8.8bn	n.a.	n.a.
Q3 2021	14	$9.7bn	n.a.	n.a.
Q4 2021	12	$8.8bn	n.a.	n.a.
Q1 2022	12	$8.9bn	n.a.	n.a.
Q2 2022	13	$8.1bn	n.a.	n.a.
Q3 2022	17	$10.8bn	n.a.	n.a.
Q4 2022	16	$13.7bn	n.a.	n.a.
Q1 2023	19	$11.5bn	n.a.	n.a.
Q2 2023	16	$10.6bn	n.a.	n.a.
Q3 2023	17	$9.7bn	n.a.	n.a.
Q4 2023	15	$10.0bn	5	9
Q1 2024	15	$7.3bn	10	6
Q2 2024	19	$12.5bn	12	8
Q3 2024	18	$15.1bn	7	11
Q4 2024	15	$12.8bn	8	7
Q1 2025	18	$14.9bn	11	7
Q2 2025	22	$18.3bn	13	10
Q3 2025	33	$26.6bn	25	8
Q4 2025	24	$23.4bn	15	28
Q1 2026	22	$17.9bn	16	18
Q2 2026	21	$15.9bn	17	18

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

ALNY and LLY →ALNY and JNJ →ALNY and VRTX →Choose a stock to compare with ALNY →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own ALNY, latest filings →Back to the 13F Explorer →

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