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SYRE in the 13F filings

Spyre Therapeutics Inc · CUSIP 00773J202

Sector · Pharmaceuticals and biotechnologyTheme · Healthcare: biopharma and medtech· L3VLUP-definedTheme · Pharmaceutical preparations
Quarter
Q2 2026Q1 2026Q4 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024
Quarter end
31 Dec 2025
the date the book describes
Filed
19 Feb 2026
latest of these filings; the earliest 11 Feb 2026
Managers listing it
17
at least, of 95 tracked, among listed positions
Comparable managers
92
filed both Q3 2025 and Q4 2025; 0 listed it in both
Shares listed
18,257,533
combined, among listed positions
Reported value
$598m
combined, at the quarter end

Among the 92 comparable managers: 13 buyers (opened or added shares) and 8 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was +5,500,092.

Managers listing SYRE in Q4 2025

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q3 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

17 of 17 holders

ActionFiling
Fidelity (FMR LLC)11,638,819$381munder 0.1%Added+2,578,67517 Feb 2026 (the filing on sec.gov)
Janus Henderson Group Ltd1,829,009$60munder 0.1%Added+1,816,00917 Feb 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc1,601,882$52munder 0.1%Added+981,26217 Feb 2026 (the filing on sec.gov)
Wellington Management Group LLP1,549,284$51munder 0.1%Trimmed-91,02817 Feb 2026 (the filing on sec.gov)
Point72 Asset Management LP662,351$22munder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
Woodline Partners LP265,892$8.7munder 0.1%Added+134,01617 Feb 2026 (the filing on sec.gov)
Capital World Investors200,172$6.6munder 0.1%Held011 Feb 2026 (the filing on sec.gov)
Invesco Ltd150,934$4.9munder 0.1%Added+100,23219 Feb 2026 (the filing on sec.gov)
Millennium Management LLC76,194$2.5munder 0.1%Trimmed-332,00517 Feb 2026 (the filing on sec.gov)
Balyasny Asset Management LLC73,465$2.4munder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
AllianceBernstein LP67,500$2.2munder 0.1%Added+31,27017 Feb 2026 (the filing on sec.gov)
Citadel Advisors LLC63,904$2.1munder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
ExodusPoint Capital Management LP37,871$1.2munder 0.1%Trimmed-30,69217 Feb 2026 (the filing on sec.gov)
AQR Capital Management LLC17,820$584kunder 0.1%Added+77317 Feb 2026 (the filing on sec.gov)
Tudor Investment Corp10,127$332kunder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP6,198$203kunder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
Susquehanna International Group LLP6,111$200kunder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)

Largest increases and reductions, by shares

There is no earlier quarter on file to compare with.

Increases

Reductions

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (6)

Exited (5)

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.
3 in Q1 2024 to 9 in Q2 2026

Tracked managers listing it, at least.

035810Q1 2024Q2 2024Q3 2024Q4 2024Q1 2025Q4 2025Q1 2026Q2 2026
the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.
SYRE by quarter
QuarterHoldersReported valueBuyersSellers
Q1 20243$23m30
Q2 20243$25m30
Q3 20243$45m21
Q4 20244$57m40
Q1 20253$15m12
Q4 20252$69m138
Q1 20265$729m127
Q2 20269$2.2bn236

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

SYRE and LLY →SYRE and JNJ →SYRE and VRTX →Choose a stock to compare with SYRE →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own SYRE, latest filings →Back to the 13F Explorer →