SYRE in the 13F filings

Spyre Therapeutics Inc · CUSIP 00773J202

Sector · Pharmaceuticals and biotechnology Theme · Healthcare: biopharma and medtech· L3VLUP-defined Theme · Pharmaceutical preparations

Quarter

Q2 2026 Q1 2026 Q4 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024 Q1 2024

Quarter end: 31 Mar 2026; the date the book describes
Filed: 18 May 2026; latest of these filings; the earliest 12 May 2026
Managers listing it: 18; at least, of 95 tracked, among listed positions
Comparable managers: 91; filed both Q4 2025 and Q1 2026; 2 listed it in both
Shares listed: 18,600,884; combined, among listed positions
Reported value: $937m; combined, at the quarter end

AllianceBernstein LP. Values in this filing are at the previous quarter end's prices; its share count is the quarter end's.

Among the 91 comparable managers: 12 buyers (opened or added shares) and 7 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was +343,351.

Managers listing SYRE in Q1 2026

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q4 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

ActionShare of book at least

18 of 18 holders

				Action		Filing
Fidelity (FMR LLC)	11,781,024	$594m	under 0.1%	Added	+142,205	15 May 2026 (the filing on sec.gov)
Wellington Management Group LLP	1,824,811	$92m	under 0.1%	Added	+275,527	15 May 2026 (the filing on sec.gov)
Janus Henderson Group Ltd	1,656,164	$84m	under 0.1%	Trimmed	-172,845	18 May 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc	1,598,730	$81m	under 0.1%	Trimmed	-3,152	15 May 2026 (the filing on sec.gov)
Capital World Investors	666,564	$34m	under 0.1%	Added	+466,392	13 May 2026 (the filing on sec.gov)
Woodline Partners LP	265,892	$13m	0.05%	Held	0	15 May 2026 (the filing on sec.gov)
Millennium Management LLC	146,639	$7.4m	under 0.1%	Added	+70,445	15 May 2026 (the filing on sec.gov)
Marshall Wace LLP	139,259	$7.0m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Invesco Ltd	132,390	$6.7m	under 0.1%	Trimmed	-18,544	12 May 2026 (the filing on sec.gov)
Citadel Advisors LLC	108,135	$5.5m	under 0.1%	Added	+44,231	15 May 2026 (the filing on sec.gov)
ExodusPoint Capital Management LP	87,065	$4.4m	under 0.1%	Added	+49,194	14 May 2026 (the filing on sec.gov)
Balyasny Asset Management LLC	55,477	$2.8m	under 0.1%	Trimmed	-17,988	15 May 2026 (the filing on sec.gov)
AllianceBernstein LP	70,900	$2.3m	under 0.1%	Added	+3,400	15 May 2026 (the filing on sec.gov)
Susquehanna International Group LLP	28,962	$1.5m	under 0.1%	Added	+22,851	15 May 2026 (the filing on sec.gov)
AQR Capital Management LLC	20,874	$1.1m	under 0.1%	Added	+3,054	15 May 2026 (the filing on sec.gov)
Man Group PLC	9,546	$482k	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Tudor Investment Corp	8,364	$422k	under 0.1%	Trimmed	-1,763	15 May 2026 (the filing on sec.gov)
Quantbot Technologies LP	88	$4k	under 0.1%	New	new	13 May 2026 (the filing on sec.gov)

Largest increases and reductions, by shares

Q4 2025 to Q1 2026, among managers that listed it in both quarters or opened it.

Increases

Capital World Investorsexisting position · 666,564 shares now+466,392
Wellington Management Group LLPexisting position · 1,824,811 shares now+275,527
Fidelity (FMR LLC)existing position · 11,781,024 shares now+142,205
Marshall Wace LLPnew position · 139,259 shares now+139,259
Millennium Management LLCexisting position · 146,639 shares now+70,445

Reductions

Janus Henderson Group Ltdexisting position · 1,656,164 shares now-172,845
Invesco Ltdexisting position · 132,390 shares now-18,544
Balyasny Asset Management LLCexisting position · 55,477 shares now-17,988
T. Rowe Price Associates Incexisting position · 1,598,730 shares now-3,152
Tudor Investment Corpexisting position · 8,364 shares now-1,763

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (3)

Exited (2)

Point72 Asset Management LPwas $22m
Brevan Howard Capital Management LPwas $203k

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.

3 in Q1 2024 to 9 in Q2 2026

Tracked managers listing it, at least.

the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

SYRE and LLY →SYRE and JNJ →SYRE and VRTX →Choose a stock to compare with SYRE →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own SYRE, latest filings →Back to the 13F Explorer →

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Quarter	Holders	Reported value	Buyers	Sellers
Q1 2024	3	$23m	3	0
Q2 2024	3	$25m	3	0
Q3 2024	3	$45m	2	1
Q4 2024	4	$57m	4	0
Q1 2025	3	$15m	1	2
Q4 2025	2	$69m	13	8
Q1 2026	5	$729m	12	7
Q2 2026	9	$2.2bn	23	6