DFTX in the 13F filings

Definium Therapeutics Inc · CUSIP 24477V105

Sector · Pharmaceuticals and biotechnology Theme · Healthcare: biopharma and medtech· L3VLUP-defined

Quarter

Q2 2026 Q1 2026 Q4 2025

Quarter end: 31 Mar 2026; the date the book describes
Filed: 27 Oct 2026; latest of these filings; the earliest 12 May 2026
Managers listing it: 26; at least, of 95 tracked, among listed positions
Comparable managers: 91; filed both Q4 2025 and Q1 2026; 1 listed it in both
Shares listed: 16,136,806; combined, among listed positions
Reported value: $305m; combined, at the quarter end

AllianceBernstein LP. Values in this filing are at the previous quarter end's prices; its share count is the quarter end's.

Among the 91 comparable managers: 25 buyers (opened or added shares) and 1 seller (trimmed or exited), at least, among listed positions. Their net change in shares was +13,108,874.

Managers listing DFTX in Q1 2026

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q4 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

ActionShare of book at least

26 of 26 holders

				Action		Filing
Janus Henderson Group Ltd	3,556,041	$67m	under 0.1%	New	new	18 May 2026 (the filing on sec.gov)
Fidelity (FMR LLC)	1,809,610	$34m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Citadel Advisors LLC	1,333,442	$25m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Wellington Management Group LLP	1,304,749	$25m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Balyasny Asset Management LLC	1,274,221	$24m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Two Sigma Investments LP	1,201,610	$23m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Marshall Wace LLP	1,200,825	$23m	under 0.1%	Trimmed	-1,774,877	15 May 2026 (the filing on sec.gov)
Holocene Advisors LP	1,091,967	$21m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Millennium Management LLC	846,896	$16m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Woodline Partners LP	752,792	$14m	0.05%	New	new	15 May 2026 (the filing on sec.gov)
D. E. Shaw & Co.	271,717	$5.1m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Jane Street Group LLC	260,241	$4.9m	under 0.1%	New	new	12 May 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP	211,488	$4.0m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Point72 Asset Management LP	175,490	$3.3m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Neuberger Berman Group LLC	133,369	$2.5m	under 0.1%	New	new	27 Oct 2026 (the filing on sec.gov)
Squarepoint Ops LLC	125,522	$2.4m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
ExodusPoint Capital Management LP	104,915	$2.0m	under 0.1%	New	new	14 May 2026 (the filing on sec.gov)
AllianceBernstein LP	91,703	$1.7m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Invesco Ltd	88,121	$1.7m	under 0.1%	New	new	12 May 2026 (the filing on sec.gov)
Susquehanna International Group LLP	81,456	$1.5m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc	70,001	$1.3m	under 0.1%	Added	+17,771	15 May 2026 (the filing on sec.gov)
AQR Capital Management LLC	57,094	$1.1m	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)
Caxton Associates LLP	37,255	$704k	under 0.1%	New	new	14 May 2026 (the filing on sec.gov)
Walleye Capital LLC	35,485	$671k	under 0.1%	New	new	13 May 2026 (the filing on sec.gov)
Schonfeld Strategic Advisors LLC	10,412	$197k	under 0.1%	New	new	15 May 2026 (the filing on sec.gov)

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Largest increases and reductions, by shares

Q4 2025 to Q1 2026, among managers that listed it in both quarters or opened it.

Increases

Janus Henderson Group Ltdnew position · 3,556,041 shares now+3,556,041
Fidelity (FMR LLC)new position · 1,809,610 shares now+1,809,610
Citadel Advisors LLCnew position · 1,333,442 shares now+1,333,442
Wellington Management Group LLPnew position · 1,304,749 shares now+1,304,749
Balyasny Asset Management LLCnew position · 1,274,221 shares now+1,274,221

Reductions

Marshall Wace LLPexisting position · 1,200,825 shares now-1,774,877

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (24)

Exited (0)

No exit shown by a manager’s own filing.

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.

1 in Q4 2025 to 9 in Q2 2026

Tracked managers listing it, at least.

the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

DFTX and LLY →DFTX and JNJ →DFTX and VRTX →Choose a stock to compare with DFTX →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own DFTX, latest filings →Back to the 13F Explorer →

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DFTX by quarter
Quarter	Holders	Reported value	Buyers	Sellers
Q4 2025	1	$40m	2	0
Q1 2026	5	$107m	25	1
Q2 2026	9	$1.1bn	17	12