DFTX in the 13F filings

Definium Therapeutics Inc · CUSIP 24477V105

Sector · Pharmaceuticals and biotechnology Theme · Healthcare: biopharma and medtech· L3VLUP-defined

Quarter

Q2 2026 Q1 2026 Q4 2025

Quarter end: 30 Jun 2026; the date the book describes
Filed: 27 Oct 2026; latest of these filings; the earliest 3 Aug 2026
Managers listing it: 24; at least, of 95 tracked, among listed positions
Comparable managers: 91; filed both Q1 2026 and Q2 2026; 4 listed it in both
Shares listed: 34,079,410; combined, among listed positions
Reported value: $1.6bn; combined, at the quarter end

AllianceBernstein LP. Values in this filing are at the previous quarter end's prices; its share count is the quarter end's.

Among the 91 comparable managers: 17 buyers (opened or added shares) and 12 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was +17,942,604.

Managers listing DFTX in Q2 2026

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q1 2026, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

ActionShare of book at least

24 of 24 holders

				Action		Filing
Janus Henderson Group Ltd	5,615,645	$264m	0.11%	Added	+2,059,604	14 Aug 2026 (the filing on sec.gov)
Capital World Investors	5,367,723	$252m	under 0.1%	New	new	12 Aug 2026 (the filing on sec.gov)
Fidelity (FMR LLC)	4,752,921	$224m	under 0.1%	Added	+2,943,311	13 Aug 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc	4,652,032	$219m	under 0.1%	Added	+4,582,031	14 Aug 2026 (the filing on sec.gov)
Wellington Management Group LLP	2,949,734	$139m	under 0.1%	Added	+1,644,985	14 Aug 2026 (the filing on sec.gov)
Citadel Advisors LLC	1,688,587	$79m	under 0.1%	Added	+355,145	2 Sep 2026 (the filing on sec.gov)
Marshall Wace LLP	1,298,946	$61m	under 0.1%	Added	+98,121	13 Aug 2026 (the filing on sec.gov)
Woodline Partners LP	1,003,641	$47m	0.15%	Added	+250,849	14 Aug 2026 (the filing on sec.gov)
Two Sigma Investments LP	921,818	$43m	under 0.1%	Trimmed	-279,792	14 Aug 2026 (the filing on sec.gov)
Balyasny Asset Management LLC	897,658	$42m	0.05%	Trimmed	-376,563	14 Aug 2026 (the filing on sec.gov)
Holocene Advisors LP	796,574	$37m	0.08%	Trimmed	-295,393	14 Aug 2026 (the filing on sec.gov)
AllianceBernstein LP	1,803,287	$34m	under 0.1%	Added	+1,711,584	14 Aug 2026 (the filing on sec.gov)
Neuberger Berman Group LLC	687,539	$32m	under 0.1%	Added	+554,170	27 Oct 2026 (the filing on sec.gov)
Point72 Asset Management LP	483,980	$23m	under 0.1%	Added	+308,490	14 Aug 2026 (the filing on sec.gov)
D. E. Shaw & Co.	315,410	$15m	under 0.1%	Added	+43,693	14 Aug 2026 (the filing on sec.gov)
Millennium Management LLC	266,076	$13m	under 0.1%	Trimmed	-580,820	14 Aug 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP	156,812	$7.4m	0.05%	Trimmed	-54,676	14 Aug 2026 (the filing on sec.gov)
AQR Capital Management LLC	134,152	$6.3m	under 0.1%	Added	+77,058	14 Aug 2026 (the filing on sec.gov)
Schonfeld Strategic Advisors LLC	119,610	$5.6m	under 0.1%	Added	+109,198	14 Aug 2026 (the filing on sec.gov)
Invesco Ltd	91,338	$4.3m	under 0.1%	Added	+3,217	14 Aug 2026 (the filing on sec.gov)
Susquehanna International Group LLP	40,954	$1.9m	under 0.1%	Trimmed	-40,502	14 Aug 2026 (the filing on sec.gov)
Walleye Capital LLC	20,643	$971k	under 0.1%	Trimmed	-14,842	3 Aug 2026 (the filing on sec.gov)
Quantbot Technologies LP	9,230	$434k	under 0.1%	New	new	12 Aug 2026 (the filing on sec.gov)
Winton Group Ltd	5,100	$240k	under 0.1%	New	new	7 Aug 2026 (the filing on sec.gov)

Largest increases and reductions, by shares

Q1 2026 to Q2 2026, among managers that listed it in both quarters or opened it.

Increases

Capital World Investorsnew position · 5,367,723 shares now+5,367,723
T. Rowe Price Associates Incexisting position · 4,652,032 shares now+4,582,031
Fidelity (FMR LLC)existing position · 4,752,921 shares now+2,943,311
Janus Henderson Group Ltdexisting position · 5,615,645 shares now+2,059,604
AllianceBernstein LPexisting position · 1,803,287 shares now+1,711,584

Reductions

Millennium Management LLCexisting position · 266,076 shares now-580,820
Balyasny Asset Management LLCexisting position · 897,658 shares now-376,563
Holocene Advisors LPexisting position · 796,574 shares now-295,393
Two Sigma Investments LPexisting position · 921,818 shares now-279,792
Brevan Howard Capital Management LPexisting position · 156,812 shares now-54,676

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (3)

Exited (5)

Jane Street Group LLCwas $4.9m
Squarepoint Ops LLCwas $2.4m
ExodusPoint Capital Management LPwas $2.0m
Caxton Associates LLPwas $704k
Verition Fund Management LLCwas $196k

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.

1 in Q4 2025 to 9 in Q2 2026

Tracked managers listing it, at least.

the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

DFTX and LLY →DFTX and JNJ →DFTX and VRTX →Choose a stock to compare with DFTX →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own DFTX, latest filings →Back to the 13F Explorer →

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DFTX by quarter
Quarter	Holders	Reported value	Buyers	Sellers
Q4 2025	1	$40m	2	0
Q1 2026	5	$107m	25	1
Q2 2026	9	$1.1bn	17	12