SNDX in the 13F filings

Syndax Pharmaceuticals Inc · CUSIP 87164F105

Sector · Pharmaceuticals and biotechnology Theme · Healthcare: biopharma and medtech· L3VLUP-defined Theme · Pharmaceutical preparations

Quarter

Q2 2026 Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024 Q1 2024 Q4 2023 Q3 2023

Quarter end: 31 Dec 2025; the date the book describes
Filed: 19 Feb 2026; latest of these filings; the earliest 10 Feb 2026
Managers listing it: 30; at least, of 95 tracked, among listed positions
Comparable managers: 92; filed both Q3 2025 and Q4 2025; 3 listed it in both
Shares listed: 13,610,024; combined, among listed positions
Reported value: $286m; combined, at the quarter end

Among the 92 comparable managers: 13 buyers (opened or added shares) and 16 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was -13,001.

Managers listing SNDX in Q4 2025

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q3 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

ActionShare of book at least

30 of 30 holders

				Action		Filing
Point72 Asset Management LP	4,882,053	$103m	0.11%	Added	+627,006	17 Feb 2026 (the filing on sec.gov)
Woodline Partners LP	1,250,668	$26m	0.10%	Trimmed	-299,852	17 Feb 2026 (the filing on sec.gov)
D. E. Shaw & Co.	1,219,609	$26m	under 0.1%	Added	+142,024	17 Feb 2026 (the filing on sec.gov)
Two Sigma Investments LP	1,146,936	$24m	under 0.1%	Added	+434,277	17 Feb 2026 (the filing on sec.gov)
AQR Capital Management LLC	925,974	$19m	under 0.1%	Added	+367,898	17 Feb 2026 (the filing on sec.gov)
Jane Street Group LLC	748,920	$16m	under 0.1%	Added	+10,654	12 Feb 2026 (the filing on sec.gov)
Two Sigma Advisers LP	632,752	$13m	under 0.1%	Added	+249,700	17 Feb 2026 (the filing on sec.gov)
ExodusPoint Capital Management LP	554,761	$12m	0.09%	Added	+482,297	17 Feb 2026 (the filing on sec.gov)
Renaissance Technologies LLC	544,800	$11m	under 0.1%	Trimmed	-315,700	12 Feb 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP	515,129	$11m	0.12%	Added	+390,554	17 Feb 2026 (the filing on sec.gov)
Citadel Advisors LLC	184,003	$3.9m	under 0.1%	Trimmed	-362,265	17 Feb 2026 (the filing on sec.gov)
Hudson Bay Capital Management LP	165,000	$3.5m	under 0.1%	Trimmed	-85,000	13 Feb 2026 (the filing on sec.gov)
Invesco Ltd	160,525	$3.4m	under 0.1%	Added	+27,434	19 Feb 2026 (the filing on sec.gov)
Fidelity (FMR LLC)	140,560	$3.0m	under 0.1%	Added	+135,459	17 Feb 2026 (the filing on sec.gov)
AllianceBernstein LP	94,880	$2.0m	under 0.1%	Trimmed	-31,769	17 Feb 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc	94,829	$2.0m	under 0.1%	Added	+3,695	17 Feb 2026 (the filing on sec.gov)
Millennium Management LLC	51,937	$1.1m	under 0.1%	Trimmed	-994,519	17 Feb 2026 (the filing on sec.gov)
Tudor Investment Corp	47,421	$996k	under 0.1%	Trimmed	-2,763	17 Feb 2026 (the filing on sec.gov)
Man Group PLC	44,638	$938k	under 0.1%	Trimmed	-130,313	17 Feb 2026 (the filing on sec.gov)
Janus Henderson Group Ltd	39,335	$827k	under 0.1%	Held	0	17 Feb 2026 (the filing on sec.gov)
Wellington Management Group LLP	35,630	$749k	under 0.1%	Trimmed	-2,596	17 Feb 2026 (the filing on sec.gov)
Walleye Capital LLC	24,205	$509k	under 0.1%	Trimmed	-273,453	13 Feb 2026 (the filing on sec.gov)
Squarepoint Ops LLC	19,814	$416k	under 0.1%	Trimmed	-15,705	13 Feb 2026 (the filing on sec.gov)
Verition Fund Management LLC	18,460	$388k	under 0.1%	Added	+1,281	13 Feb 2026 (the filing on sec.gov)
Susquehanna International Group LLP	18,153	$381k	under 0.1%	Trimmed	-16,597	17 Feb 2026 (the filing on sec.gov)

Page 1 of 2

Largest increases and reductions, by shares

Q3 2025 to Q4 2025, among managers that listed it in both quarters or opened it.

Increases

Point72 Asset Management LPexisting position · 4,882,053 shares now+627,006
ExodusPoint Capital Management LPexisting position · 554,761 shares now+482,297
Two Sigma Investments LPexisting position · 1,146,936 shares now+434,277
Brevan Howard Capital Management LPexisting position · 515,129 shares now+390,554
AQR Capital Management LLCexisting position · 925,974 shares now+367,898

Reductions

Millennium Management LLCexisting position · 51,937 shares now-994,519
Citadel Advisors LLCexisting position · 184,003 shares now-362,265
Renaissance Technologies LLCexisting position · 544,800 shares now-315,700
Woodline Partners LPexisting position · 1,250,668 shares now-299,852
Walleye Capital LLCexisting position · 24,205 shares now-273,453

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (0)

No new position among listed positions.

Exited (1)

Marshall Wace LLPwas $3.6m

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.

6 in Q3 2024 to 3 in Q2 2026

Tracked managers listing it, at least.

the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.

SNDX by quarter
Quarter	Holders	Reported value	Buyers	Sellers
Q4 2017	1	$496k	n.a.	n.a.
Q1 2018	1	$1.6m	n.a.	n.a.
Q1 2020	1	$223k	n.a.	n.a.
Q2 2020	1	$3.3m	n.a.	n.a.
Q3 2020	1	$4.1m	n.a.	n.a.
Q4 2020	7	$64m	n.a.	n.a.
Q1 2021	2	$34m	n.a.	n.a.
Q2 2021	1	$3.6m	n.a.	n.a.
Q3 2021	1	$11m	n.a.	n.a.
Q4 2021	1	$6.8m	n.a.	n.a.
Q3 2022	2	$20m	n.a.	n.a.
Q4 2022	3	$235m	n.a.	n.a.
Q1 2023	2	$159m	n.a.	n.a.
Q2 2023	5	$209m	n.a.	n.a.
Q3 2023	4	$160m	n.a.	n.a.
Q4 2023	7	$322m	6	2
Q1 2024	9	$362m	4	4
Q2 2024	8	$322m	5	2
Q3 2024	6	$117m	3	2
Q4 2024	3	$50m	0	2
Q1 2025	4	$76m	2	0
Q2 2025	3	$38m	1	1
Q3 2025	3	$89m	1	1
Q4 2025	6	$165m	13	16
Q1 2026	6	$96m	19	9
Q2 2026	3	$36m	9	19

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

SNDX and LLY →SNDX and JNJ →SNDX and VRTX →Choose a stock to compare with SNDX →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own SNDX, latest filings →Back to the 13F Explorer →

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