L3VLUP
Quarter end
31 Dec 2025
the date the book describes
Filed
19 Feb 2026
latest of these filings; the earliest 22 Jan 2026
Managers listing it
30
at least, of 95 tracked, among listed positions
Comparable managers
92
filed both Q3 2025 and Q4 2025; 6 listed it in both
Shares listed
18,216,680
combined, among listed positions
Reported value
$419m
combined, at the quarter end

Among the 92 comparable managers: 17 buyers (opened or added shares) and 17 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was -789,071.

Managers listing RARE in Q4 2025

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q3 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

30 of 30 holders

ActionFiling
Fidelity (FMR LLC)2,666,249$61munder 0.1%Trimmed-4,617,04717 Feb 2026 (the filing on sec.gov)
Wellington Management Group LLP2,461,910$57munder 0.1%Added+516,78117 Feb 2026 (the filing on sec.gov)
Citadel Advisors LLC2,326,125$54munder 0.1%Added+1,995,17217 Feb 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc1,554,366$36munder 0.1%Trimmed-755,80817 Feb 2026 (the filing on sec.gov)
AQR Capital Management LLC1,360,497$31munder 0.1%Added+614,31517 Feb 2026 (the filing on sec.gov)
Jane Street Group LLC1,021,499$23munder 0.1%Added+667,33112 Feb 2026 (the filing on sec.gov)
Millennium Management LLC880,644$20munder 0.1%Added+781,43117 Feb 2026 (the filing on sec.gov)
Schonfeld Strategic Advisors LLC741,618$17m0.08%Trimmed-402,97117 Feb 2026 (the filing on sec.gov)
Voloridge Investment Management LLC643,356$15m0.05%Added+160,77417 Feb 2026 (the filing on sec.gov)
Balyasny Asset Management LLC520,054$12munder 0.1%Newnew17 Feb 2026 (the filing on sec.gov)
Two Sigma Advisers LP481,600$11munder 0.1%Trimmed-36,10017 Feb 2026 (the filing on sec.gov)
Two Sigma Investments LP424,049$9.8munder 0.1%Added+97,86917 Feb 2026 (the filing on sec.gov)
Squarepoint Ops LLC390,599$9.0munder 0.1%Added+256,82713 Feb 2026 (the filing on sec.gov)
Renaissance Technologies LLC366,100$8.4munder 0.1%Added+344,20012 Feb 2026 (the filing on sec.gov)
D. E. Shaw & Co.344,763$7.9munder 0.1%Added+107,12317 Feb 2026 (the filing on sec.gov)
MFS Investment Management310,108$7.1munder 0.1%Trimmed-191,05522 Jan 2026 (the filing on sec.gov)
Verition Fund Management LLC282,376$6.5munder 0.1%Added+258,85613 Feb 2026 (the filing on sec.gov)
Invesco Ltd230,271$5.3munder 0.1%Trimmed-564,57819 Feb 2026 (the filing on sec.gov)
Moore Capital Management LP200,000$4.6m0.07%Trimmed-70,00017 Feb 2026 (the filing on sec.gov)
PDT Partners LLC176,813$4.1m0.26%Added+20,12017 Feb 2026 (the filing on sec.gov)
Woodline Partners LP171,805$4.0munder 0.1%Trimmed-101,44617 Feb 2026 (the filing on sec.gov)
Susquehanna International Group LLP152,316$3.5munder 0.1%Trimmed-81,81017 Feb 2026 (the filing on sec.gov)
ExodusPoint Capital Management LP137,392$3.2munder 0.1%Added+30,81717 Feb 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP107,903$2.4munder 0.1%Added+40,86817 Feb 2026 (the filing on sec.gov)
Man Group PLC78,371$1.8munder 0.1%Added+71,21917 Feb 2026 (the filing on sec.gov)
Page 1 of 2

Largest increases and reductions, by shares

Q3 2025 to Q4 2025, among managers that listed it in both quarters or opened it.

Increases

Reductions

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.
16 in Q3 2024 to 7 in Q2 2026

Tracked managers listing it, at least.

051015202014201620182020202220242026
the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.
RARE by quarter
QuarterHoldersReported valueBuyersSellers
Q1 20142$108mn.a.n.a.
Q2 20142$103mn.a.n.a.
Q3 20142$237mn.a.n.a.
Q4 20142$187mn.a.n.a.
Q1 20156$676mn.a.n.a.
Q2 20157$1.2bnn.a.n.a.
Q3 20159$1.3bnn.a.n.a.
Q4 20159$1.7bnn.a.n.a.
Q1 20163$933mn.a.n.a.
Q2 20164$461mn.a.n.a.
Q3 20166$1.1bnn.a.n.a.
Q4 20165$1.2bnn.a.n.a.
Q1 20175$1.1bnn.a.n.a.
Q2 20173$661mn.a.n.a.
Q3 20173$505mn.a.n.a.
Q4 20175$532mn.a.n.a.
Q1 20186$655mn.a.n.a.
Q2 20186$1.3bnn.a.n.a.
Q3 20186$1.3bnn.a.n.a.
Q4 20186$598mn.a.n.a.
Q1 20197$1.3bnn.a.n.a.
Q2 20197$1.3bnn.a.n.a.
Q3 20196$767mn.a.n.a.
Q4 20196$685mn.a.n.a.
Q1 20206$791mn.a.n.a.
Q2 20205$1.5bnn.a.n.a.
Q3 20206$1.6bnn.a.n.a.
Q4 20208$3.0bnn.a.n.a.
Q1 202110$2.6bnn.a.n.a.
Q2 202114$2.3bnn.a.n.a.
Q3 20219$2.0bnn.a.n.a.
Q4 20218$1.6bnn.a.n.a.
Q1 20228$1.5bnn.a.n.a.
Q2 20228$1.1bnn.a.n.a.
Q3 20226$487mn.a.n.a.
Q4 20228$604mn.a.n.a.
Q1 20239$502mn.a.n.a.
Q2 202311$619mn.a.n.a.
Q3 20238$397mn.a.n.a.
Q4 20239$593m72
Q1 202412$513m73
Q2 202413$413m102
Q3 202416$809m96
Q4 202411$243m74
Q1 20258$158m53
Q2 20257$120m43
Q3 20258$94m33
Q4 20255$43m1717
Q1 20265$48m1811
Q2 20267$396m1117

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

RARE and LLY →RARE and JNJ →RARE and VRTX →Choose a stock to compare with RARE →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own RARE, latest filings →Back to the 13F Explorer →