CTMX in the 13F filings

Cytomx Therapeutics Inc · CUSIP 23284F105

Sector · Pharmaceuticals and biotechnology Theme · Healthcare: biopharma and medtech· L3VLUP-defined Theme · Pharmaceutical preparations

Quarter

Q4 2025 Q3 2025 Q1 2024 Q2 2023 Q4 2022 Q3 2022 Q1 2022 Q4 2021 Q3 2021 Q2 2021 Q1 2021 Q4 2020

Quarter end: 31 Dec 2025; the date the book describes
Filed: 19 Feb 2026; latest of these filings; the earliest 10 Feb 2026
Managers listing it: 16; at least, of 95 tracked, among listed positions
Comparable managers: 92; filed both Q3 2025 and Q4 2025; 1 listed it in both
Shares listed: 42,351,165; combined, among listed positions
Reported value: $180m; combined, at the quarter end

Among the 92 comparable managers: 11 buyers (opened or added shares) and 5 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was +7,636,324.

Managers listing CTMX in Q4 2025

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q3 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

ActionShare of book at least

16 of 16 holders

				Action		Filing
Fidelity (FMR LLC)	24,688,109	$105m	under 0.1%	Added	+9,291,909	17 Feb 2026 (the filing on sec.gov)
Point72 Asset Management LP	5,189,538	$22m	under 0.1%	Added	+1,120,963	17 Feb 2026 (the filing on sec.gov)
Balyasny Asset Management LLC	3,872,202	$16m	under 0.1%	Trimmed	-40,879	17 Feb 2026 (the filing on sec.gov)
Woodline Partners LP	2,337,005	$10.0m	under 0.1%	Held	0	17 Feb 2026 (the filing on sec.gov)
Two Sigma Investments LP	1,560,755	$6.6m	under 0.1%	Added	+831,057	17 Feb 2026 (the filing on sec.gov)
Marshall Wace LLP	1,156,936	$4.9m	under 0.1%	Added	+51,943	13 Feb 2026 (the filing on sec.gov)
Susquehanna International Group LLP	981,598	$4.2m	under 0.1%	Added	+714,113	17 Feb 2026 (the filing on sec.gov)
Acadian Asset Management LLC	856,056	$3.6m	under 0.1%	Added	+202,331	10 Feb 2026 (the filing on sec.gov)
Jane Street Group LLC	607,218	$2.6m	under 0.1%	Added	+205,851	12 Feb 2026 (the filing on sec.gov)
Citadel Advisors LLC	342,304	$1.5m	under 0.1%	Trimmed	-1,458,131	17 Feb 2026 (the filing on sec.gov)
Two Sigma Advisers LP	335,524	$1.4m	under 0.1%	Added	+295,524	17 Feb 2026 (the filing on sec.gov)
Millennium Management LLC	289,653	$1.2m	under 0.1%	Trimmed	-1,097,210	17 Feb 2026 (the filing on sec.gov)
Hudson Bay Capital Management LP	50,990	$217k	under 0.1%	New	new	13 Feb 2026 (the filing on sec.gov)
Squarepoint Ops LLC	49,897	$213k	under 0.1%	Added	+2,169	13 Feb 2026 (the filing on sec.gov)
Invesco Ltd	21,976	$94k	under 0.1%	Trimmed	-450	19 Feb 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP	11,404	$49k	under 0.1%	New	new	17 Feb 2026 (the filing on sec.gov)

Largest increases and reductions, by shares

Q3 2025 to Q4 2025, among managers that listed it in both quarters or opened it.

Increases

Fidelity (FMR LLC)existing position · 24,688,109 shares now+9,291,909
Point72 Asset Management LPexisting position · 5,189,538 shares now+1,120,963
Two Sigma Investments LPexisting position · 1,560,755 shares now+831,057
Susquehanna International Group LLPexisting position · 981,598 shares now+714,113
Two Sigma Advisers LPexisting position · 335,524 shares now+295,524

Reductions

Citadel Advisors LLCexisting position · 342,304 shares now-1,458,131
Millennium Management LLCexisting position · 289,653 shares now-1,097,210
Balyasny Asset Management LLCexisting position · 3,872,202 shares now-40,879
Invesco Ltdexisting position · 21,976 shares now-450

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

New (2)

Exited (1)

Renaissance Technologies LLCwas $8.1m

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.

2 in Q4 2021 to 1 in Q4 2025

Tracked managers listing it, at least.

the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.

CTMX by quarter
Quarter	Holders	Reported value	Buyers	Sellers
Q1 2018	3	$12m	n.a.	n.a.
Q2 2018	1	$494k	n.a.	n.a.
Q3 2018	2	$27m	n.a.	n.a.
Q4 2018	2	$24m	n.a.	n.a.
Q1 2019	2	$8.1m	n.a.	n.a.
Q2 2019	1	$1.4m	n.a.	n.a.
Q3 2019	2	$1.4m	n.a.	n.a.
Q4 2019	3	$7.6m	n.a.	n.a.
Q1 2020	3	$1.5m	n.a.	n.a.
Q2 2020	4	$11m	n.a.	n.a.
Q3 2020	3	$5.1m	n.a.	n.a.
Q4 2020	2	$1.0m	n.a.	n.a.
Q1 2021	2	$56m	n.a.	n.a.
Q2 2021	2	$47m	n.a.	n.a.
Q3 2021	2	$33m	n.a.	n.a.
Q4 2021	2	$28m	n.a.	n.a.
Q1 2022	1	$12m	n.a.	n.a.
Q3 2022	1	$3.8m	n.a.	n.a.
Q4 2022	1	$4.2m	n.a.	n.a.
Q2 2023	1	$4.6m	n.a.	n.a.
Q1 2024	1	$5.9m	1	0
Q3 2025	1	$7.5m	1	0
Q4 2025	1	$10.0m	11	5

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

CTMX and LLY →CTMX and JNJ →CTMX and VRTX →Choose a stock to compare with CTMX →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own CTMX, latest filings →Back to the 13F Explorer →

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