L3VLUP
Quarter end
31 Mar 2026
the date the book describes
Filed
18 May 2026
latest of these filings; the earliest 12 May 2026
Managers listing it
27
at least, of 95 tracked, among listed positions
Comparable managers
91
filed both Q4 2025 and Q1 2026; 2 listed it in both
Shares listed
14,494,858
combined, among listed positions
Reported value
$490m
combined, at the quarter end

AllianceBernstein LP. Values in this filing are at the previous quarter end's prices; its share count is the quarter end's.

Among the 91 comparable managers: 14 buyers (opened or added shares) and 16 sellers (trimmed or exited), at least, among listed positions. Their net change in shares was -677,733.

Managers listing AGIO in Q1 2026

Share of 13F value is the position’s reported value over everything the manager reported that quarter. The share change is against Q4 2025, and only where both filings list the position. A rise in value with no rise in shares is the price, not buying.

27 of 27 holders

ActionFiling
Farallon Capital Management LLC5,684,000$192m1.01%Added+524,49515 May 2026 (the filing on sec.gov)
D. E. Shaw & Co.2,681,169$91m0.05%Added+843,98315 May 2026 (the filing on sec.gov)
Susquehanna International Group LLP1,344,953$46munder 0.1%Added+202,52115 May 2026 (the filing on sec.gov)
Jane Street Group LLC685,240$23munder 0.1%Trimmed-435,81012 May 2026 (the filing on sec.gov)
Wellington Management Group LLP641,486$22munder 0.1%Added+43,66015 May 2026 (the filing on sec.gov)
Citadel Advisors LLC619,613$21munder 0.1%Trimmed-729,35515 May 2026 (the filing on sec.gov)
Artisan Partners LP481,516$16munder 0.1%Trimmed-22,96913 May 2026 (the filing on sec.gov)
Marshall Wace LLP448,118$15munder 0.1%Added+94,47915 May 2026 (the filing on sec.gov)
T. Rowe Price Associates Inc298,783$10munder 0.1%Trimmed-339,10315 May 2026 (the filing on sec.gov)
Two Sigma Investments LP251,636$8.5munder 0.1%Trimmed-48,52015 May 2026 (the filing on sec.gov)
Arrowstreet Capital LP250,461$8.5munder 0.1%Newnew14 May 2026 (the filing on sec.gov)
Squarepoint Ops LLC208,888$7.1munder 0.1%Added+87,12515 May 2026 (the filing on sec.gov)
Schonfeld Strategic Advisors LLC200,061$6.8munder 0.1%Newnew15 May 2026 (the filing on sec.gov)
Invesco Ltd151,430$5.1munder 0.1%Added+8,85012 May 2026 (the filing on sec.gov)
Man Group PLC144,297$4.9munder 0.1%Newnew15 May 2026 (the filing on sec.gov)
Woodline Partners LP74,423$2.5munder 0.1%Held015 May 2026 (the filing on sec.gov)
Tudor Investment Corp58,151$2.0munder 0.1%Trimmed-3,19415 May 2026 (the filing on sec.gov)
Hudson Bay Capital Management LP51,830$1.8munder 0.1%Trimmed-48,17013 May 2026 (the filing on sec.gov)
AllianceBernstein LP61,494$1.7munder 0.1%Held015 May 2026 (the filing on sec.gov)
AQR Capital Management LLC36,410$1.2munder 0.1%Added+8,48415 May 2026 (the filing on sec.gov)
Millennium Management LLC32,144$1.1munder 0.1%Trimmed-366,12315 May 2026 (the filing on sec.gov)
Brevan Howard Capital Management LP24,469$867kunder 0.1%Added+5,13315 May 2026 (the filing on sec.gov)
Janus Henderson Group Ltd23,797$805kunder 0.1%Held018 May 2026 (the filing on sec.gov)
Balyasny Asset Management LLC18,009$609kunder 0.1%Trimmed-617,06015 May 2026 (the filing on sec.gov)
Fidelity (FMR LLC)9,121$309kunder 0.1%Trimmed-15,21315 May 2026 (the filing on sec.gov)
Page 1 of 2

Largest increases and reductions, by shares

Q4 2025 to Q1 2026, among managers that listed it in both quarters or opened it.

Increases

Reductions

New positions and exits

At least these many: a manager is shown exiting only where its own filing shows the position gone.

Ownership over time

Every quarter on file. A quarter-end value moves with the price as well as with the shares held; buyers and sellers count comparable managers, by shares.
6 in Q3 2024 to 4 in Q2 2026

Tracked managers listing it, at least.

0358102014201620182020202220242026
the quarter shown share split complete books; unmarked quarters rest on listed positionsClick a quarter to open it.
AGIO by quarter
QuarterHoldersReported valueBuyersSellers
Q3 20131$2.0mn.a.n.a.
Q4 20131$3.4mn.a.n.a.
Q1 20141$13mn.a.n.a.
Q2 20142$59mn.a.n.a.
Q3 20144$503mn.a.n.a.
Q4 20145$1.2bnn.a.n.a.
Q1 20154$1.1bnn.a.n.a.
Q2 20155$1.5bnn.a.n.a.
Q3 20155$975mn.a.n.a.
Q4 20155$922mn.a.n.a.
Q1 20165$381mn.a.n.a.
Q2 20165$326mn.a.n.a.
Q3 20167$727mn.a.n.a.
Q4 20165$306mn.a.n.a.
Q1 20177$805mn.a.n.a.
Q2 20177$823mn.a.n.a.
Q3 20179$1.1bnn.a.n.a.
Q4 20175$919mn.a.n.a.
Q1 20188$1.8bnn.a.n.a.
Q2 20188$1.8bnn.a.n.a.
Q3 20186$1.6bnn.a.n.a.
Q4 20187$835mn.a.n.a.
Q1 20197$1.4bnn.a.n.a.
Q2 20195$855mn.a.n.a.
Q3 20196$554mn.a.n.a.
Q4 20198$883mn.a.n.a.
Q1 20206$657mn.a.n.a.
Q2 20208$829mn.a.n.a.
Q3 20209$371mn.a.n.a.
Q4 20209$441mn.a.n.a.
Q1 20219$483mn.a.n.a.
Q2 20216$892mn.a.n.a.
Q3 20216$283mn.a.n.a.
Q4 20215$220mn.a.n.a.
Q1 20227$203mn.a.n.a.
Q2 20225$40mn.a.n.a.
Q3 20227$198mn.a.n.a.
Q4 20226$218mn.a.n.a.
Q1 20235$186mn.a.n.a.
Q2 20234$251mn.a.n.a.
Q3 20234$205mn.a.n.a.
Q4 20233$106m30
Q1 20245$180m32
Q2 202410$358m82
Q3 20246$332m42
Q4 20244$206m32
Q1 20253$181m11
Q2 20254$215m31
Q3 20253$250m21
Q4 20254$159m217
Q1 20265$306m1416
Q2 20264$354m1512

Compare with…

Holders over time, buyers and sellers, and the managers holding both, side by side for up to four stocks.

AGIO and LLY →AGIO and JNJ →AGIO and VRTX →Choose a stock to compare with AGIO →

How much of the picture this is

A 13F is a manager’s long US-listed equity book at a quarter end, filed up to 45 days later. It shows no shorts, cash, bonds or performance, and it is never today’s portfolio. Large books are listed to their largest positions, so a manager missing from this table may still hold a small position below that line. These are 95 tracked managers, not the institutional market.

Which funds own AGIO, latest filings →Back to the 13F Explorer →